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Cirka 2500 patienter i Sverige med opioidberoende ingår i olika substitutionsprogram och medicinerar med antingen metadon eller buprenorfin
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Suboxone rekommenderas som en del av sociala och psykoterapi method för att minska människors beroende av farliga ämnen som opioder och heroiner.
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Biverkningar vid behandling med metadon är bl a viktökning och impotens samt nedsatt libido. Vid behandling med antidoten naloxonhydroklorid
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